Depression
44 episodes · Page 2 of 2
#3248: Why Isn't Modafinil Used More for ADHD?
Modafinil boosts wakefulness and dopamine. So why does it lose to stimulants for ADHD?
#3239: Why the Brain Doesn't Fight Back Against Vyvanse
How SSRIs and Vyvanse trick the brain’s homeostatic machinery into healing instead of resisting.
#2912: Why SSRIs Can Make You Drenched at 3 AM
SSRIs can wreck your body's thermostat. Here's the neuropharmacology behind night sweats and what you can do.
#2609: Mapping the Therapy Family Tree: CBT, ACT, DBT & Beyond
How CBT, ACT, and DBT actually evolved — and why matching therapy to personality matters.
#2529: Depression Subtypes: Is It Cognitive or Biological?
Not all depression is the same. Here's what science says about melancholic, atypical, and biotype-based subtypes.
#2527: Do Brain Changes from Therapy or Pills Actually Last?
Do SSRI brain changes reverse after stopping? Can therapy physically rewire your brain for good? New neuroscience has answers.
#2484: The Alcohol-Depression Paradox: A Neurochemical Bridge
Why depressants worsen depression through rebound effects, not direct action — the real mechanism explained.
#1659: Why Your Brain Shuts Down After Months of Stress
Chronic stress isn't just mental; it physically rewires your brain. Here's the biological path from high alert to clinical depression.
#1517: The 12-Month Crash: Why Dads Hit a Depression Spike
Explore the shift to authoritative parenting, the 12-month paternal depression spike, and how AI is changing the way dads lead in 2026.
#1377: Beyond the Brain Reset: The Science of Psychedelics
Move beyond the "brain reset" metaphor to explore how psychedelics physically restructure the brain at a cellular level.
#1274: The Weight of "Mild": Understanding Chronic Depression
"Mild" depression isn't a light burden—it's a slow rot. Discover why clinical labels often fail to capture the reality of chronic low mood.
#1273: Lighting the Dark: The Science of Seasonal Depression
Discover why your brain stalls in the dark and how "personal satellites" of light can reset your internal clock to beat the winter blues.
#1261: The Frozen Psyche: The Biological Cost of Conflict
When the sirens stop, the internal alarm keeps ringing. Explore the biological and psychological footprint left by generations of conflict.
#1190: The Digital Trojan Horse: Why AI Therapy Feels Inevitable
Remote therapy was just the beginning. Discover how autonomous AI agents are evolving from digital interfaces into full-scale clinical providers.
#840: Why Antidepressants Take Weeks to Work: The Science of Lag
SSRIs change brain chemistry in hours, but mood lifts weeks later. Explore the "construction project" and neuroplasticity behind the wait.
#837: The Holy Grail That Keeps Slipping Away
Can one molecule treat both depression and ADHD? Explore the elusive "holy grail" of psychiatry: Triple Reuptake Inhibitors.
#534: Before the Pill: The Brutal History of Psychiatry
Before modern meds, doctors used ice picks and malaria to treat the mind. Herman and Corn explore the desperate, dark history of early psychiatry.
#400: Rebooting the Brain: The Science of ECT and TMS
Explore the science of "rebooting" the brain as Herman and Corn dive into ECT, TMS, and the future of treating severe depression.
#396: From Prozac to Plasticity: The New Science of Depression
Herman and Corn explore why we’re moving past SSRIs toward neuroplasticity, ketamine, and the gut-brain axis to treat depression.
#359: Why Your Diagnosis Is Just a Bundle of Symptoms
Stop treating symptoms and start treating biology. Herman and Corn explore how AI is turning medicine into a precision engineering discipline.