#psychopharmacology
60 episodes · Page 2 of 3
#3248: Why Isn't Modafinil Used More for ADHD?
Modafinil boosts wakefulness and dopamine. So why does it lose to stimulants for ADHD?
#3239: Why the Brain Doesn't Fight Back Against Vyvanse
How SSRIs and Vyvanse trick the brain’s homeostatic machinery into healing instead of resisting.
#3130: How to Fight Better: The Science of Healthy Conflict
The first 3 minutes of a fight predict divorce with 90% accuracy. Here’s what to do about it.
#2965: How Your Liver Actually Processes Drugs
The five half-life rule, grapefruit juice warnings, and why some drugs don't follow the rules.
#2912: Why SSRIs Can Make You Drenched at 3 AM
SSRIs can wreck your body's thermostat. Here's the neuropharmacology behind night sweats and what you can do.
#2891: Do ADHD Drug Holidays Actually Work?
The science behind taking breaks from stimulant medication—does it reset dopamine or just disrupt treatment?
#2890: Hyperfocus Isn't a Superpower
When focus becomes a trap. The signs of overmedication, the dopamine crash, and why you can't stop.
#2889: How ADHD Meds Actually Work in Your Brain
What happens neurochemically when you adjust your stimulant dose — and why more isn't always better.
#2720: Does More Money Actually Make You Happier?
The $75K happiness threshold is outdated. New research shows the real relationship between income and well-being is more nuanced.
#2663: When Opposing Drugs Cooperate
Two opposing drugs collide in your system. Do they cancel out or work together?
#2609: Mapping the Therapy Family Tree: CBT, ACT, DBT & Beyond
How CBT, ACT, and DBT actually evolved — and why matching therapy to personality matters.
#2607: Life Coaching vs Therapy: How to Choose
Life coaching, therapy, or something else? A practical framework for navigating the confusing world of helping professions.
#2584: Why ADHD Meds Feel Cleaner Than Coffee
The neurochemical difference between caffeine and prescription ADHD drugs isn't about strength — it's about mechanism.
#2579: Why You Feel Watched (And Why You're Not)
Why sitting alone in public feels so awkward — and what the research says you can do about it.
#2562: Why Do Humans Love Food That Burns?
The science of why we enjoy pain from chili peppers, from ancient domestication to modern hot sauce culture.
#2533: Can Ibogaine Really Reset Addiction?
A deep dive into ibogaine's anti-addictive potential, cardiac risks, and the push for FDA-approved analogs.
#2529: Depression Subtypes: Is It Cognitive or Biological?
Not all depression is the same. Here's what science says about melancholic, atypical, and biotype-based subtypes.
#2484: The Alcohol-Depression Paradox: A Neurochemical Bridge
Why depressants worsen depression through rebound effects, not direct action — the real mechanism explained.
#1803: Why Hostages Defend Their Captors
A tech exec was brainwashed in 2025. The neurochemistry is the same as Stockholm Syndrome.
#1769: Affirmations & Visualization: Science vs. Wishful Thinking
We unpack the $43B personal development industry: why "I am lovable" can make you feel worse and how mental rehearsal actually rewires your brain.
#1726: 2500 Years of Bad Medicine: The Slow Surrender
Bloodletting dominated medicine for 2500 years. Here’s how science finally admitted it was wrong.
#1664: Why Your Face Leaks Before Your Brain Approves
Why do we cry at sad movies or laugh at bad jokes? New research reveals how facial expressions evolved as a two-way communication system.
#1660: How Hostage Negotiators Really Work (Not Like the Movies)
Forget the lone hero with a headset. Real crisis negotiation is a team sport built on psychology and timing.
#1646: How State Brainwashing Actually Works
From North Korea's civil religion to Iran's child recruitment, regimes use three core levers to control populations. The psychology is sophisticate...