#psychopharmacology
66 episodes · Page 2 of 3
#3315: NPD Unpacked: From Pinel to Treatment
How clinicians finally separated personality disorders from mood disorders—and what that means for treatment today.
#3275: Why the Same Antidepressant Hits Different People Completely Differently
Two people, same drug, opposite outcomes. The answer is in your liver enzymes and brain receptors.
#3270: How SSRIs Actually Rewire Your Brain (and What Happens When You Stop)
The brain builds an entire scaffold on antidepressants. Why does it get torn down so fast when you stop?
#3269: Why Your Mental Health Labels Might Be Wrong
Most people with mental illness have multiple diagnoses. What if the labels are the problem, not the patient?
#3255: Catatonia Beyond the Frozen Statue
Catatonia isn't just frozen stillness—it's a motor dysregulation syndrome more common in mania than schizophrenia.
#3253: Nicotine Receptors & Bupropion: How an Antidepressant Blocks Smoking
How bupropion hijacks nicotinic receptors to cut smoking reward and withdrawal — and why these receptors aren't really "nicotine" receptors.
#3248: Why Isn't Modafinil Used More for ADHD?
Modafinil boosts wakefulness and dopamine. So why does it lose to stimulants for ADHD?
#3239: Why the Brain Doesn't Fight Back Against Vyvanse
How SSRIs and Vyvanse trick the brain’s homeostatic machinery into healing instead of resisting.
#3130: How to Fight Better: The Science of Healthy Conflict
The first 3 minutes of a fight predict divorce with 90% accuracy. Here’s what to do about it.
#2965: How Your Liver Actually Processes Drugs
The five half-life rule, grapefruit juice warnings, and why some drugs don't follow the rules.
#2912: Why SSRIs Can Make You Drenched at 3 AM
SSRIs can wreck your body's thermostat. Here's the neuropharmacology behind night sweats and what you can do.
#2891: Do ADHD Drug Holidays Actually Work?
The science behind taking breaks from stimulant medication—does it reset dopamine or just disrupt treatment?
#2890: Hyperfocus Isn't a Superpower
When focus becomes a trap. The signs of overmedication, the dopamine crash, and why you can't stop.
#2889: How ADHD Meds Actually Work in Your Brain
What happens neurochemically when you adjust your stimulant dose — and why more isn't always better.
#2720: Does More Money Actually Make You Happier?
The $75K happiness threshold is outdated. New research shows the real relationship between income and well-being is more nuanced.
#2663: When Opposing Drugs Cooperate
Two opposing drugs collide in your system. Do they cancel out or work together?
#2609: Mapping the Therapy Family Tree: CBT, ACT, DBT & Beyond
How CBT, ACT, and DBT actually evolved — and why matching therapy to personality matters.
#2607: Life Coaching vs Therapy: How to Choose
Life coaching, therapy, or something else? A practical framework for navigating the confusing world of helping professions.
#2584: Why ADHD Meds Feel Cleaner Than Coffee
The neurochemical difference between caffeine and prescription ADHD drugs isn't about strength — it's about mechanism.
#2579: Why You Feel Watched (And Why You're Not)
Why sitting alone in public feels so awkward — and what the research says you can do about it.
#2562: Why Do Humans Love Food That Burns?
The science of why we enjoy pain from chili peppers, from ancient domestication to modern hot sauce culture.
#2533: Can Ibogaine Really Reset Addiction?
A deep dive into ibogaine's anti-addictive potential, cardiac risks, and the push for FDA-approved analogs.
#2529: Depression Subtypes: Is It Cognitive or Biological?
Not all depression is the same. Here's what science says about melancholic, atypical, and biotype-based subtypes.
#2484: The Alcohol-Depression Paradox: A Neurochemical Bridge
Why depressants worsen depression through rebound effects, not direct action — the real mechanism explained.